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avon catalogue 12 download adobe photoshop cs5 download trial adobe fireworks cs4 download completo bullguard antivirus 2013 free download for mobile The aggregate score using the apps rating, amount of users, and a amount of other parameters closely connected to user satisfaction. The most effective score is 10. No specific information on version 6.0. Please visit the primary page of ChemWindow on Software Informer. The aggregate score using the apps rating, variety of users, and a amount of other parameters closely associated with user satisfaction. The most beneficial score is 10. ChemWindow may be the software chemists decide for chemical structure drawing and publishing worldwide. It also offers integrated methods to modify, store, search, and retrieve chemical structures and properties. ChemWindow offers scientists a lot more solutions. Chemistry Database Building structures, chemical - property information, etc. Chemical Drawing Programs The Comparison of Accelrys Symyx Draw, ChemBioDraw ChemDraw, DrawIt, ChemSketch, ChemDoodle and These pages work flawlessly simply with Javascript enabled! If you might have any comment, don't hesitate to contact the writer at the above mentined address. The site will be updated. The following changes are planned: The immense progression of microelectronics has banished folks who suffer typing machine, drawing pen, Indian ink and templates. Instead, text editors like MS Word, Corel WordPerfect or Lotus WordPro are of general use today. With the aid of these it's possible to create professional looking articles and drawings, plus a large amount of time for your rewriting, redrawing and making corrections could be spared likewise. The introduction of chemical structures using the conventional drawing programs would be extremely painstaking and tough. With publication at heart aesthetics and quality visit the front, ensured by built-in templates, bonds constrained to fixed length and angles, etc. Direct 3D editing is generally not possible 3D options that come with a molecule could be visualised only with the wedged/hashed bond drawing methodology. The availability of numerous tools palette of fonts, arrows, lines and curves, arcs and also other shapes or graphic primitives, etc. is usually of high importance. If a true 3D representation with the molecule should be used, its import at a modelling program or 3D data base will be the most feasible arrangement although recent drawing packages usually have a simple 2D 3D converter module or add-in. The presented drawing computer programs work about the Windows or McIntosh platforms, some under Linux likewise. An important requirement is WYSIWYG What You See Is What You Get. Under the Windows OS most tasks printing, screen and printer fonts, resolution or other system wide parameter are maintained by Windows itself and its particular set-up may be the determining factor. Another important point may be the user-friendliness with the program. This means that an individual interface in the program, which ensures the interactive two-way communication between the consumer and the machine, must be simple but effective. The information sharing for some other programs also needs to be many-sided. Accelrys Symyx Draw 4.1 Academic edition ChemBioDraw Ultra 14.0 ChemDraw ACD/ChemSketch 12.0 Free and Commercial DrawIt - KnowItAll Academic Edition 9.0 WinPLT, ICM-Chemist, ChemPen, XDrawChem, JChemPaint, BKChem, ChemicPen, ChemTool, ICEdit, SketchEI, TouchMol, JavaGrinsl standalone drawing applications JME Editor, WebME Molecular Editor, ChemWriter, ChemVector, JDraw, JSDraw, Xemistry sketcher, JMolDraw, MCDL applets Chem4Word, TouchMol for Office add-ins for MS Office Although every one of these software packages are stand-alone applications, these are members of integrated suites also, and they also serve as the input modules of other database and modelling programs or full information management systems. The distinction between and ranking in the lead applications is just not so straightforward anymore: in your first version of the review 1998 only three programs were included ChemWindow, ChemBioDraw and Isis/Draw high were considerable differences totally, your chance modules in the recent programs are alongside. Although the state name is Accelrys Draw now, this course installs itself as Symyx Draw, like a member in the Isentris and Accelrys Direct information systems and Accelrys Electronic Laboratory Notebook. Accelrys Draw would be the face-lifted new incarnation from the old ISIS/Draw with and more user-friendly interface. A few extra features concerning mainly database use have already been added, some drawing tools are already refined while a number of other ones aren't supported anymore. It is surely an alternative input modul to its own plus the Reaxys databases at the same time. Java applet version: JDRaw. ChemBioDraw is integrated together with the ChemBioOffice, E-Notebook along with data management applications Ensemble for Chemistry. The drawing of biological objects are actually developed lately also as integration with databases with Scifinder recently. Available as Windows or Mac version. Version 13 has more bugs than its predecessors, version 14 is much better. The ChemBioDraw for iPad is usually a considerably simplified version meant for basic molecular editing. ChemSketch may be the input modul of ChemFolder as well as some other applications on the ACD suite. It has several modules, extensions, and add-ins with regards to the calculation of physical-chemical properties, import, processing and databasing of spectra and chromatograms, naming of molecules, prediction of NMR spectra, etc. Available as Windows or being an older Linux version. A new player in neuro-scientific chemical editors is ChemDoodle for Windows, Mac and Linux. It has everything essential for creating publication quality chemical documents. It is integrated with ChemDoodle Web Components and ChemDoodle Mobile iOS and Android phones. Its architecture is sort of different from those in the old-timers, it possesses a handful of very helpful brand new tools, a couple of new question-of-taste ones and a few less impeccable features also. In addition to structure and document editing features it includes several tools a variety of them called widgets for instance constitutional and physicochemical descriptors and properties, embedding, editing and simulation of spectra, etc. The main drawback from the previous versions that round-trip editing was obviously a bit cumbersome inside Windows has become resolved. SoftShells old ChemWindow has melted to the KnowItAll application suite and continues to be split to DrawIt and ReportIt separate molecular editor and general editor applications, rogues is to import objects including structures and spectra, set them up on the page, and add text, annotations, reaction arrows, orbitals and other graphical objects when I consider DrawIt later, it means always ReportIt, too. The DrawIt modules from the ChemWindow and Academic editions are similar. The latest version of Chemistry 4-D Draw contains slight improvements over the earlier ones. The commercial version of Chemistry 4-D Draw is integrated using its Chem4D database and nomenclature modules depending within the purchased version. Available as Windows or Mac version. Special mention should be made on MarvinSketch. This is an intriguing and very dynamically developing Java-based multiplatform chemical editor for drawing structures, reactions and queries with excellent features for web applications. It may be the input module with the JChem Base chemical information management system in addition to many other ones including Reaxys. Its general editing properties, support of other graphical objects and texts will not be as polished and complex as those inside above six applications for that time being, it will not be a publishing software, therefore no full comparison continues to be made. However, its chemical editing properties are incredibly similar as well as in a couple of respects, particularly the creation of query structures. The basic version contains several tools and plugins which might be fully missing from your other applications or are offered only by separately purchasing them. Although MarvinSketch is discussed only briefly and separately in the end on this review, it can be referenced and compared at several points. The different extensions add-ins, plug-ins, bundled programs come while using purchased versions, sometimes might be freely downloaded, sometimes has to be purchased separately, sometimes are available as a possible Internet-service - therefore before you make decisions it's highly recommended to go to the homepages of the programs also to inform, what modules are still included within the price in the program version being considered. These are briefly reviewed in Table 1. and nearby the end with this review. The database and other functions with the programs usually are not considered within this review, but structure drawing capabilities and text functions have already been probed in great details and aspects. As extended and detailed discussions of any features are unattainable, an important comparisons are summarised in Table 2. Bold text indicates features which are already considered clearly beneficial when compared to the other programs, while italizations point out weak points. Of course, we have been aware in the subjectivity of those comparisons. On the other hand, only 10-20% with the users are advanced ones: those reading and checking the written or online documentation in depth, trying everything, and knowing such handy tools or tricks, that are unknown for the everyday user. The automatic installers with the programs support customised setup. As most with the programs comprise several optional modules, it really is advisable to pick the custom setup mode also to select the modules really necessary. All installation procedures were flawless except ChemBioOffice 13 Ultra: even choosing custom setup mode, the correct dialog window had not been initialised plus the full package was installed checked under Windows XP, Vista and 7/64 versions. This has become fixed in version 14. Every program has a number specific, proprietary input/output file formats with unique file name extensions. These associations are usually entered into your Windows registry. Most programs will be able to deal with a number of other file formats, too. During the setup process some programs can be aggressive and change the file name associations set previously by others. Fortunately, none on the reviewed chemical softwares behave that way and most turn out polite enough to question in a dialog box how to deal with the foreign file types should the other program can also be installed in your PC, dont allow to affect the corresponding associations. A rule with every software program that useful documents often! This is true inside the case from the reviewed programs, too. Although they may be generally stable enough, ChemBioDraw suffers mostly from rare and unexpected crashes. File operations, data movement Beyond the essential file input and output operations, the export and import facilities to/from other applications are of high importance. For example, if a person has to import a 3D structure from your modelling program or embed an illustration put together by another drawing program. There are two basic chemical file types: program-specific sketch files, including all objects with the drawing, and molecule files or molfiles, used largely by modelling and database programs, these contain just the description from the molecules. Not regarding its very own proprietary file formats MDL SKC and MOL molfiles Accelrys Draw features a narrow range of export/import possibilities, mainly molecule and database file filters can be found. Chemistry 4-D Draw accepts only MDL molfiles likewise. MDL sketch files are sustained by ChemBioDraw and ChemSketch, and the opposite way round, Accelrys Draw now sports ths import of ChemBioDraw CDX files. ChemDoodle also supports the key foreign sketch files. However, be equipped for inaccuracies over the import: fine tuning from the imported sketches is generally necessary. Of course, the not mutually supported features or objects are not imported. DrawIt often crashed when experimented with open ChemBioDraw files. MarvinSketch gets the Document to Structure input mode: it sports ths grabbing and opening of embedded structures from common Office document formats: DOC, DOCX, PPT, PPTX, XLS, XLS, ODT as well as PDF, XML, HTML and TXT. Support of Web-related file formats will also be included inside the latest versions CML in ChemSketch and XML in ChemBioDraw and ChemDoodle, UniProt XML in Accelrys Draw; with the time being, these formats are usually in quite experimental phase yet and never of general use. To summarize, ChemBioDraw and ChemSketch will be the most respected applications accompanied by ChemDoodle and MarvinSketch, these applications retain the highest volume of export/import filters although despite intensive beta-testing not all turn out to be bug-free. During the evolution of such applications the structures that belongs to them proprietary file formats evolved too. Therefore backward-compatibility has never been granted. For the time being, mentioned have to be made around the following backward-compatibility issues: DrawIt will not support the older CW2 format of the company's predecessor ChemWindow. Accelrys Draw As far as chemistry is involved the backward-compatibility of ISIS/Draw created skc files is 100%. In the truth of other graphical objects it is just not fully compatible having its predecessor most with the differences between ISIS Draw and Accelrys Draw are discussed to use Help. Some cosmetic and restyling ought to be necessary when utilizing old files. The old TGF file format isn't supported anymore. Not too important, though it might be valuable in special cases. Therefore dont delete the oldie but goldie ISIS Draw. In ChemBioDraw 12 the handling of colours has become altered. Some surprises might happen in drawings using many colours differently coloured shaded objects, or when pasting objects into other applications. For example, shaded or filled boxes behave differently. Other small inconsistencies are actually found, too, by way of example arrows and font sizes of drawings manufactured with earlier versions changed when opening in ChemBioDraw 12-14. Therefore have tests before updating big projects, like hundreds of figures for text books, in the event. Personally, I still use ChemBioDraw 11 when handling old projects. No backward compatibility issues were experienced inside the case of ChemSketch, 12-13 yrs . old files of posters look flawless within the recent version. This mainly concerns ChemBioDraw, ChemSketch and DrawIt because they applications are suitable for creating big size posters containing a group of several data types. If illustrations, charts, diagrams can be imported from another application, rather than bitmap images JPG, TIF, GIF, etc. vector formats Windows metafiles WMF or EMF, SVG, PDF must be preferred: the first kind ones can not be resized without considerable decrease in quality, therefore the printed images can look ragged, uneven. In some new versions the SVG vector format can be supported. The next table summarises the import possibilities of various files and clipboard objects in the programs: As shown from the above table, MarvinSketch cannot import graphical images, however, using the aid with the third-party application OSRA chemical images is usually converted to real chemical structures. OSRA Optical Structure Recognition Application can be a handy utility created to convert graphical representations of 2D chemical structures obtained in GIF, JPEG, PNG, TIFF, PDF, PS, etc. documents. The OSRA plug-in can be obtained for Accelrys Draw 4 and ChemBioDraw 12, too. Accelrys Draw, ChemBioDraw and ChemSketch come with an Insert object option at the same time direct calling of some other Windows applications. Advanced users may go through with it, the final results are mixed. With the exception of DrawIt the programs have support for converting and saving the documents in other graphical bitmap formats. Avoid the utilization of JPG format as it's suitable exclusively for photographic images. The lossless GIF or PNG extendable can directly be utilized for creating internet pages. To learn more about the GIF, JPG and PNG formats look at this side bar. High resolution TIFF images are desired by the traditional printing process. ChemDoodle supports several bitmap and vector graphical file formats, too. When the by using 2D vector graphics makes sense, SVG Scalable Vector Graphics, an XML-based extendable is an open standard nowadays for browsers and web applications. The general editor ReportIt supports a vast variety of spectroscopic and chromatographic data formats, therefore it truly is surprising so it has no input/output methods of WMF, EMF and at least a couple of common bitmap formats. Nevertheless, the export/import through the clipboard was flawless. In ChemBioDraw 12-14 you will find problems when saving the documents in certain bitmap formats. When trying to avoid wasting big multipage documents in PNG format, occassionally null files are designed. When saving in TIFF or PNG format, indexed kit is used obsolete 256 colour mode, meaning that the colours of shaded objects and the anatomy, animals, etc. templates are distorted. PNG files are unchangeably saved with transparent backgrounds, this might be problematic for unexperienced users. Fortunately, you will find no problems inside the case with the most important task: the direct transfer on the drawings between these programs as well as other applications text editors, Powerpoint, etc. The general object linking and embedding OLE procedure from the Windows applications can be obtained: first-time the drawing may be copied and pasted through the Windows clipboard or drag-and-dropped in to the text editor. To edit later, double clicking on your chance in the text editor or while using right-click pop-up menu starts enter program and moves here is your chance into it automatically round-trip editing. Chemistry 4D Draw can accept sketches in MDL skc format in the clipboard, but only chemical objects molecules are supported. Unfortunately, embedded ChemWindow drawings in older documents can't be opened in the text editor and edited in DrawIt, to put it differently, the ChemWindow object doesn't exist anymore. Moreover, it is unattainable to copy/past structures as chemical entities from DrawIt holiday to a chemical applications, the structures appear only as graphics. This is really a serious drawback. You need to export them as mol files. Accelrys Draw: Delocalized aromatic rings will not show, when they're copy/pasted into another application while using the default paste operation. Use Paste as or Paste special and select the Windows metafile emf option. The latest versions of ChemDoodle already fully supports OLE procedures. Generally speaking, direct import through Windows clipboard is really a complicated procedure behind happens. When a program sends a drawing for the clipboard, a mixture of various formats can be used: the proprietary formats with the application, MDLs molfile in text or clipboard format, sketch or reaction file, different picture formats, Windows metafile formats wmf and emf, etc. On pasting the marked program should recognise and use the proper ones. Advanced users can fine-tune in ChemDoodle what on earth is copied to your clipboard Although caffeine drawings embedded in to a MS Word, WordPro or WordPerfect document could be re-opened and edited by their creator program later round-trip editing, sometimes this technique may fail: if your full document is interconverted Word WordPerfect, etc. or maybe a newer version in the text editor refreshes a vintage document, the hidden link between image as well as its creator program may mysteriously vanish. As a result, the image is not edited anymore. Therefore ensure you always beneficial complicated drawings through the chemical drawing program in their native format, too! When a sketch is pasted from any chemical applications to Powerpoint, a fancy of results are inserted with it. This is normally unnecessary. Instead of using Paste, open Paste if available and select Picture enhanced metafile. The amount of information is a smaller amount, and also the Powerpoint file will likely be much smaller, especially inside case of numerous illustrations. Older laptops are going to be grateful. The drawback on this method is the fact chemistry will not be pasted together while using graphics, put simply, you cant round-trip edit the sketch from the original program anymore by just double-hitting it. So use it only within the case from the final sketch, otherwise you could have to delete and copy/paste it again from your chance application. An important feature is the fact that ChemBioDraw, ChemDoodle, ChemSketch and DrawIt and can easily create multiple page documents or posters. The Open file dialog of ChemDoodle, MarvinSketch and DrawIt has a simple but useful quick preview pane. The preview pane in ChemDoodle contains also a magnifier, too. It displays a simplified version on the content on the current file. It greatly helps the positioning of a sketch or molecule, every time a folder contains 200-300 of older files. The other programs should likewise consider the support of an similar feature. Another helpful add-on of ChemSketch, ChemBioDraw and ChemDoodle could be the quick look for structures feature. Contrary to ChemDoodle, this feature just isn't available inside basic versions of ChemBioDraw and ChemSketch, because doing so depends about the search engine on the corresponding database programs. In ChemSketch it enables a persons to seek out chemical structures on his or her file system in various chemical sketch and molfile formats at the same time as PDF, Word, Excel and Powerpoint documents and ACD databases, using exact or substructure search. The content in the matched files may be inspected inside the preview window and opened in ChemSketch or inside application which come up with file. In the ChemOffice suite, ChemFinder for Office is often a similar stand-alone utility able to browsing MS Office documents with OLE objects and ISIS and ChemBioDraw files. For the time being, it is sort of slower rather than so reliable as that certain in ChemSketch, one example is ChemFinder for Office 11 and 12 produced different hit lists in the same list of test files while using the same preferences. ChemDoodle searches in supported sketch and molecule files. The content on the matched files and structures might be inspected from the preview window and opened for editing. The basic operations, as as an example the sprouting or free hand drawing of bonds, enter and joining of rings, the resizing of elements or even the whole sketch etc, are handled well by all from the six programs. In Chemistry 4-D Draw the moving from the different objects can't be constrained on the horizontal or vertical direction. The next figure depicts the disposable different bond types. Some turn out query types also, but may be used well in special circumstances. Mainly by Accelrys Draw, ChemBioDraw, ChemSketch and MarvinDraw several database features are supported: query atom and bond types, advanced Markush structures, chemically significant multicenter attachments to resonance delocalized fragments, polymers, reaction features, atom-atom mapping etc., these are certainly not covered here. In ChemSketch there is really a separate handy option button for your direct drawing of bonds with solid or dotted delocalization curves. Of course such structures, as effortless drawings, is usually assembled manually too. Chemically interpreted multicenter coordinative bonds, like the ferrocene molecule are offered in ChemBioDraw, ChemSketch and Accelrys Draw. Of course, similar structures may be assembled manually from odds and ends, when underlying chemistry is unimportant. In all recent versions these applications but Chemistry 4-D Draw virtually any parameter of the object along with their elements could be independently restyled and trimmed, a very beneficial feature in advanced hands. In the truth of Chemistry 4-D Draw the parameters of the full object could be modified, although not part with the object. ChemSketch applies pseudo empty atoms for that bent bonds, like those employed in carbohydrates. Similarly, ChemBioDraw uses pseudoatoms for multicenter bonds, including metal atoms coordinated to ferrocene. When converting to 3D structures in the suit the programs automatically eliminate these, but will need to take care when exporting such structures to a new applications. When three-dimensional structures are imported, the recent versions of most programs are already effective at 3D rotation. Each program is able for the automatic addition of hydrogens, although they are only implicit hydrogens, as well as the saved file is not going to contain them. ChemSketch, ChemDoodle and MarvinSketch has a option to convert and add implicit hydrogens as explicit, physical ones. This feature would be the less sophisticated in DrawIt, one example is no implicit hydrogens are included in imported molecule files or corrected when editing the link order later. Chemistry 4-D Draw Pro, when working with its intelligent NamExpert feature, can produce structures from chemical names in three styles: the generally used shorthand structure, the linear semistructural plus the so-called KekulР№ structure would be the three available choices unfortunately, a later interconversion between styles is unattainable. Note also the very helpful Lewis dot structures for sale in ChemDoodle: All in the programs possess a Clean up structure function, which redraws and resizes selected structures or fragments to standardize all the call lengths and angles. None of them has precedence in the others: they actually do their best and create nice-looking structures, but may fail in or less difficult ring systems. When putting it on in ChemBioDraw 12-13, the algorythm often rotates flips even quite simple structures, this really is unfriendly inside our opinion. ChemBioDraw 14 behaves better All in the programs can perceive aromaticity and replace optionally the double bonds with aromatic delocalised rings. Accelrys Draw cannot export aromatic rings via copy/past method into other applications, though. The basic default and user settings might be saved and recalled in most programs, moreover, additional settings styles to make documents according to your demands of some common journals may also be available. ChemDoodle contains several previously unknown or extended editing features, as an example undo/redo with history window, automatic sizing of brackets to content, extended techniques for centering or rearranging the objects, stack everything onpage, saturate or kekulize molecule, graph reduction, etc. Some of these could be really useful and some belong towards the question-of-taste category. ChemDoodle also contains tools for explicitly defining and building reactions in a very separate dialog window. The reaction partners, reaction conditions, arrows and signs are automaticaly assembled and formatted. This tool is just not for building reaction queries for database searches. Its adventage may be the quick and uniform formatation think about the dozens or many reactions within a textbook, nevertheless, you might have little control above the hard-wired layout one example is, automatic arrangement of vertical arrows will not be fully supported. Smiles, SLN or InChi strings formulation of chemical structures in the line of text used mainly to facilitate the search in databases are held by ChemSketch, ChemBioDraw, Accelrys Draw, ChemDoodle and MarvinSketch. When you open a file in this type which has a text editor you observe something like this: Strings will not contain coordinates, therefore as you move the conversion back in 2-dimensional representations of small molecules successful, from the case of large cyclic compounds the result are going to be chemically correct but quite ugly looking. The best results were obtained with ChemBioDraw when you use Smiles strings as you move the others performed variously. For a not commented tiny comparison see this There are several commercial and experimental applications around to transform line notation of big molecules into acceptable 2D drawings. Delicate 3D structures really should be imported from modelling programs. However, most of the applications have modules or bundled programs, add-ins, which might be capable of 2D 3D conversion: Except Chem3D many of these modules are free of charge or come while using basic versions. Take into consideration that other than Chem3D, these modules contain only simple MM optimisation algorithms plus the produced conformer is usable exclusively for presentation purposes or as starting stage to get more rigorous minimisations. Using the peptide, carbohydrate and nucleic acid builder on the ChemSketch/ChemBasic Goodies, complicate 3D molecules is usually created by inputting their shorthand text abbreviation. The automatic conversion of 3D structures towards the usual 2D shorthand drawings using standard bond lengths and angles has become problematic. Nice drawings are generally produced only within the case of small molecules. A test is made using a 3D molecule file of josamycin, a macrolide antibiotic. Only the disposable options were put to use, sometimes repeatedly or perhaps combinations. The results: Obviously the most up-to-date applications MarvinSketch and ChemDoodle did the top job. While ChemBioDraw couldn't produce satisfactory 2D structures from your bigger 3D molfile on a unique, this can be more successful if you could have Chem3D, too. When the ChemBioDraw pane is active within Chem3D in dual link mode the default case, edition or rotation on the 3D model is reflected simultaneously inside the ChemBioDraw pane, the structure is on-the-fly changed to a 2D drawing. When the 2D model looks satisfactory, it could be saved or copied towards the stand-alone ChemBioDraw program for even more modification. This handy tool to generate peptides or nucleic acid sequences are a part of Accelrys Draw, ChemBioDraw and ChemDoodle without stereochemistry. The one seen in ChemSketch is usually a quite immature version. The enhanced version of ChemBioDraw 13 and 14 sports ths addition of - and D-amino acids, disulfide bridges and also the creation of cyclopeptides and arbitrary links between peptide chains. Protecting groups may also be added, but this function isn't going to play well: the modified labels cannot be expanded, including the example described within the manual could hardly be reproduced. ChemDoodle has interactive templates for creating arbitrary carbon nanotubes and prisms. The width and height on the nanotube might be changed by moving the mouse horizontally or vertically. Double bonds are going to be automatically placed. A new feature in ChemBioDraw, ChemSketch, Accelrys Draw, ChemDoodle and MarvinSketch could be the optional drawing and/or export of sketches in anti-aliased mode: the elimination in the stair-step appearance of sloping or curved lines. This greatly adds to the quality of drawings when exported to Powerpoint presentations or as images to website pages. Anti-aliasing doesn't have a influence on printing the resolution with the printers is really a lot higher than that with the screen. As it is really a quite resource-demanding feature, inside case of slower, older computers and big multipage documents you might turn it off while enter is being prepared. The ChemBioDraw solution could be the more advanced one: anti-aliasing is optionally used when pasting the drawings into other applications Powerpoint, etc. or saving as images or metafiles. ChemSketch uses only screen anti-aliasing could be circumvented by usage of a screen-capture application. The anti-aliasing in Accelrys Draw can not be turned off unfriendly solution because when moving sketches into other applications using the Windows clipboard, sometimes not all in the objects are anti-aliased. The drawing of various lines, polygons, circles and arcs, curves, arrows, etc. were also tested. Of course, no advanced popular features of a professional general drawing program must be expected, but basic functions are offered and they are usually enough to make, as an example, simple diagrams or biochemical sketches. In this respect ChemBioDraw and ChemSketch include the best: they contain more graphical objects as opposed to other programs, for the other hand, these might be filled with simple or shaded colours and/or patterns. It is odd that pattern-filled objects will not be supported in ChemBioDraw anymore. The support of Bezier curves to generate free-form, irregular curves or shapes could be the best in ChemSketch. Customizations of filling and colouring of objects and shadow would be the most advanced in ChemSketch. With ChemSketch a shaded double DNA helix is usually created in a few minutes. However, the revolutionary BioDraw templates of ChemBioDraw make the development of DNA a lot more easier. Different basic atomic orbitals are offered in all programs although in a variety of quality. As mentioned earlier, in ChemBioDraw 12 the handling of colours was changed. This might cause problems within the back compatibility of drawings with a lot of colors. The shadowed rectangles, etc. behave differently too, and also a white box with black shadow can not be created regardless of whether trying to build it from two pieces. The drawings of figure A were designed with ChemBioDraw. The daunorubicin DNA complex is coming from a Protein Data Bank file PDB308D: the extracted structure was positioned having a 3D modelling program, utilized in ChemBioDraw as molecule file plus some final touches were added. The middle sketch was produced with ChemSketch. A very powerful new feature of ChemBioDraw 10-13 will be the BioDraw palettes and toolbar. Versions of ChemBioDraw on this new tool are classified as Chem BioDraw. The BioDraw toolbar contains adjustable templates to attract enzymes, receptors, cell membranes, DNA, immunoglobulins, laboratory animals, etc. figure B. BioArt templates have already been added the most recent ChemDoodle at the same time. As for that rotations of objects, ChemBioDraw and ChemDoodle would be the most advanced: both chemical structures and caption texts could be freely rotated; the rotation on the atom labels can be an option. ChemWindow and ChemSketch rotate the caption text, yet not the structural text and atom symbols. Accelrys Draw and Chemistry 4-D Draw are certainly not able to rotate caption text in any way. The rotation of chemical structures along with objects may be important from the case of full-page figures: sometimes the use on the landscape mode can be necessary, but 90 image rotation is just not available within a less sophisticated text editor. To summarize : ChemBioDraw and ChemSketch are about neck and neck. When creating complex drawings through the available graphical objects ChemSketch is in all likelihood a hairs breadth ahead. ChemBioDraw or especially ChemBioDraw gets the adventage when assembling from templates. The drawing of laboratory glassware or process flow diagrams can be quite handy in DrawIt: the library files possess a vast amount of drawings and chemical engineering symbols. ChemSketch, ChemBioDraw and ChemDoodle also contain templates for glassware right image; additional templates are downloadable: A very helpful feature in ChemBioDraw and ChemDoodle will be the TLC plate tool, especially for your users of laboratory e-notebooks. It allows the consumer to create and depict easily TLC plates with origin line, solvent front, and several lanes. The lanes might be populated with spots of numerous Rf, size, shape, or colour, sufficient reason for option for automatic display of Rf values. A similar TLC tool is obtainable in ChemSketch, too, for an installable extension, but compared to your direct graphical editing on the former two it can be quite clumsy data needs to be applied for a dialog table. A new gel electrophoresis tool may be added to ChemBioDraw 13. Another important feature may be the possibility with the restyling of drawing objects, one example is the change with the appearance of arrows, the width of lines or bonds, margin width, font size and so forth. Current settings is usually saved coming from all programs and recall and apply later. Especially useful are definitely the predefined journal settings or style sheets. These are incredibly flexible inside recent versions of applications but also in Chemistry 4-D Draw. In Chemistry 4-D Draw merely the parameters of your full object is usually modified, and not part with the object. In the other applications there could possibly be some properties that is usually set only globally, though, one example is the display of aromatic delocalized circles in Accelrys Draw. The technical realisations truly must be different: one example is in ChemSketch floating toolboxes are employed, in ChemBioDraw right-click menus. An inherited a weakness in ChemBioDraw would be the apply of favor sheets and restyling of objects. No problems when building a new document by opening a layout sheet. However, when reapplying a method sheet for an existing document or changing document settings, not all with the new parameters are consequently applied. When drawings are copy/pasted between two documents with assorted settings, structural text is changed accordingly, but captions not at all times: odd font-size values might appear. Another bug inside the latest versions of ChemBioDraw that on while using Apply object settings from current document option on imported structures, a clean-up procedure is additionally applied which might ruin already nicely polished structures. Thirdly, when a structure is dowloaded and inserted into a preexisting document with the Find structure from name at ChemACX way the document settings bond length, bond width, etc. are changed unexpectedly! Could stuck being a great surprise later. Therefore it truly is highly recommended to place such structures right into a temporal document first then to copy it into its final place. Hopefully, these glitches will likely be fixed sometimes Quite serious and incredibly annoying bug in Accelrys Draw that after globally restyling an adult document changing bond width or turning aromatic circles on or off positions in the objects in many cases are messed up and actual settings are re-applied not merely the changed one. In addition, this is not undone. Chemical Drawing Programs The Comparison of Accelrys Symyx Draw, ChemBioDraw ChemDraw, DrawIt, ChemSketch, ChemDoodle and These pages work flawlessly just with Javascript enabled! If you've any comment, don't hesitate to contact the article author at the above mentioned address. The site is now being updated. The following changes are planned: The immense growth of microelectronics has banished using a typing machine, drawing pen, Indian ink and templates. Instead, text editors like MS Word, Corel WordPerfect or Lotus WordPro are of general use today. With the aid of these it's possible to create professional looking articles and drawings, as well as a large amount of time for that rewriting, redrawing and making corrections could be spared too. The development of chemical structures while using conventional drawing computer software would be extremely painstaking and tough. With publication at heart aesthetics and quality arrived at the front, ensured by built-in templates, bonds constrained to fixed length and angles, etc. Direct 3D editing is often not possible 3D popular features of a molecule may be visualised only utilizing the wedged/hashed bond drawing methodology. The availability of several tools palette of fonts, arrows, lines and curves, arcs along with other shapes or graphic primitives, etc. can also be of high importance. If a true 3D representation in the molecule is required, its import coming from a modelling program or 3D data base would be the most feasible arrangement even though the recent drawing packages usually possess a simple 2D 3D converter module or add-in. The presented drawing computer software work for the Windows or McIntosh platforms, some under Linux also. An important requirement is WYSIWYG What You See Is What You Get. Under the Windows OS most tasks printing, screen and printer fonts, resolution and other system wide parameter are maintained by Windows itself and it is set-up will be the determining factor. Another important point will be the user-friendliness on the program. This means that an individual interface from the program, which ensures the interactive two-way communication between the person and the machine, needs to be simple but effective. The information sharing for some other programs also needs to be many-sided. Accelrys Symyx Draw 4.1 Academic edition ChemBioDraw Ultra 14.0 ChemDraw ACD/ChemSketch 12.0 Free and Commercial DrawIt - KnowItAll Academic Edition 9.0 WinPLT, ICM-Chemist, ChemPen, XDrawChem, JChemPaint, BKChem, ChemicPen, ChemTool, ICEdit, SketchEI, TouchMol, JavaGrinsl standalone drawing applications JME Editor, WebME Molecular Editor, ChemWriter, ChemVector, JDraw, JSDraw, Xemistry sketcher, JMolDraw, MCDL applets Chem4Word, TouchMol for Office add-ins for MS Office Although these software packages are stand-alone applications, they can be members of integrated suites also, and they also serve as the input modules of other database and modelling computer software or full information management systems. The distinction between and ranking in the lead applications just isn't so straightforward anymore: in your first version in this review 1998 only three programs were included ChemWindow, ChemBioDraw and Isis/Draw and then there were considerable differences totally, here is your chance modules with the recent programs are alongside each other. Although the state run name is Accelrys Draw now, this course installs itself as Symyx Draw, as being a member with the Isentris and Accelrys Direct information systems and Accelrys Electronic Laboratory Notebook. Accelrys Draw will be the face-lifted new incarnation with the old ISIS/Draw with an all new and more user-friendly interface. A few extra features concerning mainly database use have already been added, some drawing tools are actually refined while a couple of other ones aren't supported anymore. It is surely an alternative input modul to its own as well as the Reaxys databases also. Java applet version: JDRaw. ChemBioDraw is integrated while using ChemBioOffice, E-Notebook along with data management applications Ensemble for Chemistry. The drawing of biological objects happen to be developed lately too as integration with databases with Scifinder recently. Available as Windows or Mac version. Version 13 has more bugs than its predecessors, version 14 is best. The ChemBioDraw for iPad is usually a considerably simplified version created for basic molecular editing. ChemSketch may be the input modul of ChemFolder and many other applications in the ACD suite. It has several modules, extensions, and add-ins regarding the calculation of physical-chemical properties, import, processing and databasing of spectra and chromatograms, naming of molecules, prediction of NMR spectra, etc. Available as Windows or being an older Linux version. A new player in chemical editors is ChemDoodle for Windows, Mac and Linux. It has everything required for creating publication quality chemical documents. It is integrated with ChemDoodle Web Components and ChemDoodle Mobile iOS and Android phones. Its architecture is sort of different from those in the old-timers, it possesses a great handful of invaluable brand new tools, a couple of new question-of-taste ones and several less impeccable features at the same time. In addition to structure and document editing features it includes several tools a number of them called widgets like constitutional and physicochemical descriptors and properties, embedding, editing and simulation of spectra, etc. The main drawback on the previous versions that round-trip editing would be a bit cumbersome from the Windows may be resolved. SoftShells old ChemWindow has melted into your KnowItAll application suite and may be split to DrawIt and ReportIt separate molecular editor and general editor applications, aforementioned is to import objects for example structures and spectra, put them on the page, and add text, annotations, reaction arrows, orbitals or another graphical objects when I make reference to DrawIt later, it means always ReportIt, too. The DrawIt modules with the ChemWindow and Academic editions are similar. The latest version of Chemistry 4-D Draw contains slight improvements over the prior ones. The commercial version of Chemistry 4-D Draw is integrated featuring its Chem4D database and nomenclature modules depending around the purchased version. Available as Windows or Mac version. Special mention have to be made on MarvinSketch. This is an intriquing, notable and very dynamically developing Java-based multiplatform chemical editor for drawing structures, reactions and queries with excellent features for web applications. It could be the input module on the JChem Base chemical information management system as well as many other ones for instance Reaxys. Its general editing properties, support of other graphical objects and texts usually are not as polished and complex as those within the above six applications to the time being, it just isn't a publishing software, therefore no full comparison is made. However, its chemical editing properties are certainly similar maybe in a couple of respects, specially the creation of query structures. The basic version contains several tools and plugins which can be fully missing in the other applications or can be purchased only by separately purchasing them. Although MarvinSketch is discussed only briefly and separately for the end with this review, it's referenced and compared at several points. The different extensions add-ins, plug-ins, bundled programs come while using purchased versions, sometimes could be freely downloaded, sometimes has to be purchased separately, sometimes are available just as one Internet-service - therefore prior to making decisions it's highly recommended to go to the homepages of the programs and inform, what modules are presently included from the price with the program version being considered. These are briefly reviewed in Table 1. and near to the end in this review. The database and other functions in the programs will not be considered within this review, but structure drawing capabilities and text functions are actually probed in great details and aspects. As extended and detailed discussions of the features are impossible, the key comparisons are summarised in Table 2. Bold text indicates features which are already considered clearly beneficial than the other programs, while italizations examine weak points. Of course, were aware in the subjectivity of these comparisons. On the other hand, only 10-20% on the users are advanced ones: those reading and checking written or online documentation in more detail, trying everything, and knowing such handy tools or tricks, which might be unknown to your everyday user. The automatic installers with the programs support customised setup. As most in the programs comprise several optional modules, it really is advisable to select the custom setup mode also to select exactly the modules really necessary. All installation procedures were flawless except ChemBioOffice 13 Ultra: even choosing the custom setup mode, the proper dialog window hasn't been initialised and also the full package was installed checked under Windows XP, Vista and 7/64 versions. This is fixed in version 14. Every program has a number of specific, proprietary input/output file formats with unique file name extensions. These associations will almost always be entered into your Windows registry. Most programs can easily deal with other file formats, too. During the setup process some programs are usually aggressive and change the file name associations set previously by others. Fortunately, none from the reviewed chemical softwares behave in this way and most seem to be polite enough ought to in a dialog box how to deal with the foreign file types should the other program is usually installed in your PC, dont allow to modify the corresponding associations. A guideline with every software that useful documents often! This is true within the case with the reviewed programs, too. Although they're generally stable enough, ChemBioDraw suffers mostly from rare and unexpected crashes. File operations, data movement Beyond the essential file input and output operations, the export and import facilities to/from other applications are of high importance. For example, if you has to import a 3D structure coming from a modelling program or embed an illustration manufactured by another drawing program. There are two basic chemical file types: program-specific sketch files, including all objects with the drawing, and molecule files or molfiles, used largely by modelling and database programs, these contain exactly the description in the molecules. Not regarding its proprietary file formats MDL SKC and MOL molfiles Accelrys Draw incorporates a narrow selection of export/import possibilities, mainly molecule and database file filters can be purchased. Chemistry 4-D Draw accepts only MDL molfiles also. MDL sketch files are held by ChemBioDraw and ChemSketch, and the other way round, Accelrys Draw now sports ths import of ChemBioDraw CDX files. ChemDoodle also supports the most crucial foreign sketch files. However, be ready for inaccuracies throughout the import: fine tuning with the imported sketches is frequently necessary. Of course, the not mutually supported features or objects are not imported. DrawIt often crashed when aimed to open ChemBioDraw files. MarvinSketch has got the Document to Structure input mode: it props up the grabbing and opening of embedded structures from common Office document formats: DOC, DOCX, PPT, PPTX, XLS, XLS, ODT together with PDF, XML, HTML and TXT. Support of Web-related file formats will also be included inside the latest versions CML in ChemSketch and XML in ChemBioDraw and ChemDoodle, UniProt XML in Accelrys Draw; with the time being, these formats come in quite experimental phase yet instead of of general use. To summarize, ChemBioDraw and ChemSketch will be the most respected applications and then ChemDoodle and MarvinSketch, these applications offer the highest variety of export/import filters although notwithstanding intensive beta-testing not all turn out bug-free. During the evolution of the applications the structures of their proprietary file formats evolved at the same time. Therefore backward-compatibility is not granted. For the time being, mentioned need to be made within the following backward-compatibility issues: DrawIt doesn't support the older CW2 format of their predecessor ChemWindow. Accelrys Draw As far as chemistry can be involved the backward-compatibility of ISIS/Draw created skc files is 100%. In the truth of other graphical objects it just isn't fully compatible featuring its predecessor most from the differences between ISIS Draw and Accelrys Draw are discussed in their Help. Some cosmetic and restyling really should be necessary when working with old files. The old TGF file format will not be supported anymore. Not too important, though it might be valuable in special cases. Therefore dont delete the oldie but goldie ISIS Draw. In ChemBioDraw 12 the handling of colours has become altered. Some surprises might happen in drawings using many colours differently coloured shaded objects, or when pasting objects into other applications. For example, shaded or filled boxes behave differently. Other small inconsistencies are actually found, too, by way of example arrows and font sizes of drawings designed with earlier versions changed when opening in ChemBioDraw 12-14. Therefore have tests before updating big projects, for example hundreds of figures for text books, in the event that. Personally, I still use ChemBioDraw 11 when handling old projects. No backward compatibility issues were experienced inside case of ChemSketch, 12-13 years of age files of posters look flawless inside recent version. This mainly concerns ChemBioDraw, ChemSketch and DrawIt because they applications are suitable for creating big size posters containing a group of several data types. If illustrations, charts, diagrams have to be imported from another application, as an alternative to bitmap images JPG, TIF, GIF, etc. vector formats Windows metafiles WMF or EMF, SVG, PDF needs to be preferred: the first sort ones can not be resized without considerable loss in quality, hence the printed images look ragged, uneven. In some new versions the SVG vector format is additionally supported. The next table summarises the import possibilities of several files and clipboard objects into your programs: As shown inside the above table, MarvinSketch cannot import graphical images, however, with all the aid in the third-party application OSRA chemical images might be converted to real chemical structures. OSRA Optical Structure Recognition Application is usually a handy utility made to convert graphical representations of 2D chemical structures obtained in GIF, JPEG, PNG, TIFF, PDF, PS, etc. documents. The OSRA plug-in can be obtained for Accelrys Draw 4 and ChemBioDraw 12, too. Accelrys Draw, ChemBioDraw and ChemSketch come with an Insert object option too direct calling of one other Windows applications. Advanced users can suffer with it, the effects are mixed. With the exception of DrawIt the programs have support for converting and saving the documents in other graphical bitmap formats. Avoid the by using JPG format as it's suitable simply for photographic images. The lossless GIF or PNG extendable can directly be utilized for creating webpages. To learn more about the GIF, JPG and PNG formats check out this side bar. High resolution TIFF images are desired by the traditional printing process. ChemDoodle supports several bitmap and vector graphical file formats, too. When the using 2D vector graphics makes sense, SVG Scalable Vector Graphics, an XML-based formatting is an open standard nowadays for browsers and web applications. The general editor ReportIt supports a vast quantity of spectroscopic and chromatographic data formats, therefore it truly is surprising so it has no input/output alternatives for WMF, EMF and at least some common bitmap formats. Nevertheless, the export/import through the clipboard was flawless. In ChemBioDraw 12-14 you can find problems when saving the documents in most bitmap formats. When trying to avoid wasting big multipage documents in PNG format, occassionally null files are designed. When saving in TIFF or PNG format, indexed shirt is used obsolete 256 colour mode, hence the colours of shaded objects or perhaps the anatomy, animals, etc. templates are distorted. PNG files are unchangeably saved with transparent backgrounds, this might be problematic for unexperienced users. Fortunately, you'll find no problems inside case with the most important task: the direct transfer in the drawings between these programs as well as other applications text editors, Powerpoint, etc. The general object linking and embedding OLE procedure on the Windows applications is accessible: very first time that the drawing may be copied and pasted with the Windows clipboard or drag-and-dropped in to the text editor. To edit later, double clicking on your chance in the text editor or with all the right-click pop-up menu starts your chance program and moves here is your chance into it automatically round-trip editing. Chemistry 4D Draw can accept sketches in MDL skc format in the clipboard, but only chemical objects molecules are supported. Unfortunately, embedded ChemWindow drawings in older documents can not be opened through the text editor and edited in DrawIt, basically, the ChemWindow object won't exist anymore. Moreover, it is unattainable to copy/past structures as chemical entities from DrawIt holiday to a chemical applications, the structures appear only as graphics. This can be a serious drawback. You need to export them as mol files. Accelrys Draw: Delocalized aromatic rings don't show, when they're copy/pasted into another application while using the default paste operation. Use Paste as or Paste special and select the Windows metafile emf option. The latest versions of ChemDoodle already fully supports OLE procedures. Generally speaking, direct import through Windows clipboard is really a complicated procedure behind happens. When a program sends a drawing on the clipboard, a mixture of several formats is utilized: the proprietary formats in the application, MDLs molfile in text or clipboard format, sketch or reaction file, different picture formats, Windows metafile formats wmf and emf, etc. On pasting the objective program should recognise and use the proper ones. Advanced users can fine-tune in ChemDoodle precisely what is copied to your clipboard Although caffeine drawings embedded in a MS Word, WordPro or WordPerfect document may be re-opened and edited by their creator program later round-trip editing, sometimes this action may fail: in the event the full document is interconverted Word WordPerfect, etc. or maybe a newer version with the text editor refreshes a classic document, the hidden link relating to the image as well as creator program may mysteriously vanish. As a result, the image can't be edited anymore. Therefore be sure to always keep your complicated drawings through the chemical drawing program in their native format, too! When a sketch is pasted from any chemical applications to Powerpoint, a fancy of information is inserted involved with it. This is generally unnecessary. Instead of using Paste, open Paste if available and select Picture enhanced metafile. The amount of information is a lot less, as well as the Powerpoint file is going to be much smaller, especially inside the case of countless illustrations. Older laptops will probably be grateful. The drawback of the method is always that chemistry just isn't pasted together while using graphics, put simply, you cant round-trip edit the sketch from the original program anymore by just double-simply clicking it. So put it to use only within the case with the final sketch, otherwise you've to delete and copy/paste it again from your chance application. An important feature is ChemBioDraw, ChemDoodle, ChemSketch and DrawIt and will be able to create multiple page documents or posters. The Open file dialog of ChemDoodle, MarvinSketch and DrawIt includes a simple but useful quick preview pane. The preview pane in ChemDoodle contains a magnifier, too. It displays a simplified version from the content in the current file. It greatly helps the venue of a sketch or molecule, whenever a folder contains 200-300 of older files. The other programs must also consider the support of an similar feature. Another helpful add-on of ChemSketch, ChemBioDraw and ChemDoodle could be the quick look for structures feature. Contrary to ChemDoodle, this feature is just not available inside the basic versions of ChemBioDraw and ChemSketch, given it depends within the search engine in the corresponding database programs. In ChemSketch it enables you to seek out chemical structures for their file system in several chemical sketch and molfile formats too as PDF, Word, Excel and Powerpoint documents and ACD databases, using exact or substructure search. The content in the matched files is usually inspected inside the preview window and opened in ChemSketch or within the application which come up with file. In the ChemOffice suite, ChemFinder for Office is really a similar stand-alone utility effective at browsing MS Office documents with OLE objects and ISIS and ChemBioDraw files. For the time being, it is sort of slower rather than so reliable as that you in ChemSketch, by way of example ChemFinder for Office 11 and 12 produced different hit lists through the same pair of test files with all the same preferences. ChemDoodle searches in supported sketch and molecule files. The content from the matched files and structures is usually inspected within the preview window and opened for editing. The basic operations, as one example is the sprouting or free hand drawing of bonds, enter and joining of rings, the resizing of elements and the whole sketch etc, are handled well by all on the six programs. In Chemistry 4-D Draw the moving from the different objects can not be constrained for the horizontal or vertical direction. The next figure depicts possible different bond types. Some turn out to be query types at the same time, but might be used well in special circumstances. Mainly by Accelrys Draw, ChemBioDraw, ChemSketch and MarvinDraw several database features are supported: query atom and bond types, advanced Markush structures, chemically significant multicenter attachments to resonance delocalized fragments, polymers, reaction features, atom-atom mapping etc., these usually are not covered here. In ChemSketch there can be a separate handy option button with the direct drawing of bonds with solid or dotted delocalization curves. Of course such structures, as effortless drawings, is usually assembled manually too. Chemically interpreted multicenter coordinative bonds, including the ferrocene molecule can be obtained in ChemBioDraw, ChemSketch and Accelrys Draw. Of course, similar structures might be assembled manually from things, when underlying chemistry is unimportant. In all recent versions of the applications but Chemistry 4-D Draw virtually any parameter of the object as well as their elements may be independently restyled and trimmed, a invaluable feature in advanced hands. In the truth of Chemistry 4-D Draw the parameters of the full object could be modified, however, not part in the object. ChemSketch applies pseudo empty atoms to the bent bonds, like those utilized in carbohydrates. Similarly, ChemBioDraw uses pseudoatoms for multicenter bonds, for instance metal atoms coordinated to ferrocene. When converting to 3D structures inside suit the programs automatically eliminate these, but have to take care when exporting such structures to a different applications. When three-dimensional structures are imported, the recent versions of the programs are already efficient at 3D rotation. Each program is able towards the automatic addition of hydrogens, although these are typically only implicit hydrogens, and also the saved file is not going to contain them. ChemSketch, ChemDoodle and MarvinSketch has a option to convert and add implicit hydrogens as explicit, physical ones. This feature could be the less sophisticated in DrawIt, for instance no implicit hydrogens are included with imported molecule files or corrected when editing the call order later. Chemistry 4-D Draw Pro, when you use its intelligent NamExpert feature, can produce structures from chemical names in three styles: the generally used shorthand structure, the linear semistructural plus the so-called Kekul Organic and Medicinal Chemistry Letters Full text beta-Keto esters from ketones and ethyl chloroformate: a quick, general, efficient synthesis of pyrazolones in addition to their antimicrobial, in silico as well as in vitro cytotoxicity studies Below is often a snapshot from the Web page since it appeared on 12/15/2015. This could be the version with the page that's used for ranking pursuit results. The page could have changed given it was last cached. To see what probably have changed without worrying about highlights, go to your current page. We have highlighted matching words that appear inside the page below. Yahoo! is just not responsible to the content of the page. 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